In response to the limitations of conventional cancer treatments, our approach emphasizes evidence-based integrative therapies. These therapies target universal hallmarks of cancer cells in both primary tumors and metastases, providing a holistic and personalized treatment strategy. Integrative therapies combine innovative metabolic interventions with traditional approaches, aiming to enhance efficacy while minimizing side effects. Key components include:

1. A package of inhibitors of the aerobic glycolysis and glutaminolysis like genistein, oxythiamine, DCA and ketone bodies derivates, blocking the entry of glucose and glutamine into the tumor cells. All free of side effects both in animal and human studies.
2. Inhibitors of the carboanhydrase mediated extracellular acidosis like acetazolamide, sulphonamides or coumarins, all free of side effects.
3. High dose intravenous Vitamin C, specifically oxidizing at tumor site in the presence of increased metal concentrations with generation of superoxide radical and hydrogen peroxide, both of them inducing the apoptosis/necrosis of tumor cells. Free of side effects.
4. Natural polyphenols like curcumin, artemisinin, EGCG or substituted phenols, generating superoxide and semiquinone radicals in the presence of increased heavy metal consentrations at the tumor site.
5. The inhibition of the intracellular redosis in cancer cells by means of pro-oxidative interventions such as hyperthermia, short term fasting (3-5 days), ketogenic diet and regular physical exercise.
6. A personalised combination of the above mentioned interventions with an appropriate form of Immunotherapy with check-point-inhibitors like nivolumab, pembrolizumab, atezolizumab etc, in line with the therapy resistance tests on circulating tumor cells.
7. An appropriate form of nutrition with low glycemic index low in sugar, flour products, glutamine, iron, nickel, zinc, chromium, folic acid, fat peroxides and alcohol, but rich in omega-3-fatty acids, vitamin D, carotenoids. plant proteins, selected amino acids, sphingolipids, phytosterols, isoflavonoids, polyphenols, L+lactic acid and pro-oxidative vegetable juices.

By integrating these strategies, our therapy approach addresses not only the tumors themselves but also the underlying conditions that sustain cancer growth. This comprehensive and evidence-backed method has shown promise in overcoming resistance and improving patient outcomes.

For a deeper insight in our cancer therapy concept please consider our peer reviewed original paper “Metabolic hallmarks of cancer cells as targets for integrative therapies” published in the Journal of Translational Science, 2020.